Tolerance to Non-Opioid Analgesics is Opioid Sensitive in the Nucleus Raphe Magnus
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چکیده
منابع مشابه
Tolerance to Non-Opioid Analgesics is Opioid Sensitive in the Nucleus Raphe Magnus
Repeated injection of opioid analgesics can lead to a progressive loss of effect. This phenomenon is known as tolerance. Several lines of investigations have shown that systemic, intraperitoneal administration or the microinjection of non-opioid analgesics, non-steroidal anti-inflammatory drugs (NSAIDs) into the midbrain periaqueductal gray matter induces antinociception with some effects of to...
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C describe the concept of multimodal analgesia and give examples Abstract Opium is the natural substance to which modern narcotics owe their existence. First discovered in the 1500s, opium was the most potent analgesic compound in use, held in high regard, hence its Latin name laudanum (to praise). Subsequent studies into the effects of opium led to the discovery of the opioid receptors, and th...
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B. Bie,1 H. L. Fields,2 J. T. Williams,3 and Z. Z. Pan1 1Departments of Symptom Research and Biochemistry and Molecular Biology, University of Texas–M. D. Anderson Cancer Center, Houston, Texas 77030, 2Departments of Neurology and Physiology and the Wheeler Center for the Neurobiology of Addiction, University of California San Francisco, San Francisco, California 94143, and 3Vollum Institute, O...
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Intensive research on the neurobiology of pain over the past two decades has revealed many receptors, ion channels and enzymes with potential as novel targets for development of a new generation of analgesic agents. However, despite large investment in preclinical and clinical development of small molecules and biologics as potential novel pain therapeutics, very few have reached the clinic. He...
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Paracetamol has analgesic and antipyretic e ects that are similar to aspirin, but little or no antiin ammatory activity. It is generally accepted that it has little e ect on extracerebral COX-1 or COX-2, although it inhibits central COX-3. Consequently, it prevents the enhanced synthesis of prostaglandin E2 in the hypothalamus during pyrexia, and thus reduces elevated body temperature. It has s...
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ژورنال
عنوان ژورنال: Frontiers in Neuroscience
سال: 2011
ISSN: 1662-4548
DOI: 10.3389/fnins.2011.00092